Spontaneous fractures in a 30-year-old woman following a simple fall.

To cite: James R, James J, Vij AS, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2013201994 DESCRIPTION We describe the case of a 30-year-old woman who presented with breathing difficulty and a history of spontaneous fractures. The possibility of primary hyperparathyroidism was kept in mind and the patient was evaluated. The initial laboratory assessment revealed the following results: Parathyroid hormone (PTH) level markedly raised, PTH 2642 pmol/L (normal 1.2–5.8 pmol/L) Hypercalcaemia, with corrected calcium 3.78 mmol/L (normal 2.05–2.55 mmol/L) Hypophosphataemia 0.4 mg/dL (normal 0.8–1.5 mmol/L) Vitamin D 62 pmol/L (normal 60–108 pmol/L) Alkaline phosphatase 958 U/L (normal 30–120 U/L) Haemoglobin 5.4 g/dL (normal 12–15 g/dL) Total leucocyte count 8649/mL (normal 4500–11 000/mL) Erythrocyte sedimentation rate 14 mm/h (normal 01–22 mm/h) C reactive protein 13.6 mmol/L (normal 0.76–28.5 mmol/L) Random blood sugar 109 mg/dL (normal 70–120 mg/dL) Blood urea 30 mg/dL (normal 20–40 mg/dL) Creatinine 0.7 mg/dL (normal 0.1–1.2 mg/dL) Sodium 135 mmol/L (normal 135–145 mmol/L) Potassium 3.7 mmol/L (normal 3.5–5.5 mmol/L) Chloride 102 mmol/L (normal 96–106 mmol/L) Magnesium 2.1 mg/dL (normal 1.3–2.1 mmol/L). Arterial blood gas investigations revealed partial pressure of oxygen 90 mm Hg and partial pressure of carbon dioxide 30.2 mm Hg, and pH 7.34 An ultrasound scan of the neck showed a right inferior lobe parathyroid adenoma, which was further confirmed by a Sesta MIBI scan (figures 1–3). An emergency surgery opinion was taken and the patient underwent excision of a parathyroid adenoma measuring 5.9×4.5 cm. Following surgery, within 24 h the PTH levels dropped to a normal level (5.3 pmol/L). Initial treatment for this patient was administration of pamidronate 60 mg as a single dose, given intravenously as a slow infusion over 12 h along with 5% dextrose normal saline (DNS) 100 mL/h infusion. Three days after surgery, the patient developed hungry bones syndrome manifesting as symptomatic hypocalcaemia with signs and symptoms such as a positive Chvostek’s sign, carpopedal spasm and paraesthesias. This syndrome occurs because of rapid calcium deposition into the bone after levels of PTH have normalised, causing serum calcium levels to decrease. This was managed with injection of calcium gluconate 10% 10 mL every 6 h intravenously along with oral calcium carbonate and oral calcitriol. Hungry bone syndrome can be avoided by frequent monitoring of serum calcium levels and careful attention to laboratory evidence and clinical signs and symptoms of hypocalcaemia. Orthopaedic surgeons managed the femoral fractures with bilateral femoral nailing. The patient was discharged on oral calcium carbonate 500 mg twice daily, oral calcitriol and oral alendronate. Figure 1 X-ray of the skull showing multiple rounded radio-opaque shadows indicating ‘moth-eaten’/cystic lesions.